When playing from the screen?

I have 2 monitors and next to gaming i often watch twitch or youtoube (for music), but i can't get out of some games (e.g. League of legends, sims 4) i always have to press ctrl + esc, but that takes a lot time, are there other ways?

Play in window mode?

I know this problem. Unfortunately, it can't be prevented…

I bought the Elgato Streamdeck so I can pause the video with the push of a button. 🙃