Taxi drivers have an enlarged hippocampus. In reality, taxi drivers drive through the streets and everything is saved in their memory.
Is that the same in virtual reality? For example, you drive a Mario Kart on Nintendo 64 and memorize all routes, or you play banjo kazooie and save everything in your memory: Is the hippocampus enlarged as well as for taxi drivers?
Yes, with more knowledge, more synapses form.
There's no difference whether you memorize a thing in the real world or in a video game.
The principle is the same.
however, taxi drivers drive taxis far more often than you do your kart in Mario